Bioactive Small Molecules
Selleck Chemical LLC Elacestrant S9629-10MM/1ML
Elacestrant (RAD1901) Dihydrochloride is an orally available selective estrogen receptor degrader (SERD) with IC50 of 48 nM and 870 nM for ER and ER respectively
Selleck Chemical LLC MKC8866 S8875-25MG
MKC8866 (IRE1-IN-8866) a salicylaldehyde analog is a specific IRE1 RNase inhibitor with IC50 of 0 29 M for human IRE1 in vitro
Selleck Chemical LLC Kavain S9409-1MG
Kavain (( )-Kavain) the main kavalactone found mostly in the roots of the kava plant has anticonvulsive properties attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na and Ca2 channels Kavain positively modulated -Aminobutyric acid type A (GABAA) receptor
Selleck Chemical LLC Tropifexor S8733-2MG
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with EC50 of 0 2 nM in HTRF assay It shows no significant off-target activity against a broad panel of enzyme ion channel nuclear receptor and GPCR ( 10000-fold selectivity for FXR)
Medchemexpress LLC Kaempferitrin | 482-38-2 | 578.52 | 25 MG
Kaempferitrin is a natural flavonoid known for its diverse biological activities. It possesses antinociceptive, anti-inflammatory, anti-diabetic, antitumoral, and chemopreventive effects, and plays a role in activating the insulin signaling pathway. This compound has demonstrated utility in both in vitro and in vivo studies for various research applications.
- Activates the insulin signaling pathway.
- Exhibits antinociceptive, anti-inflammatory, anti-diabetic, antitumoral, and chemopreventive effects.
- Increases insulin receptor beta tyrosine phosphorylation and stimulates Akt phosphorylation.
- Promotes GLUT4 translocation and increases total Glu4 protein levels.
- Cytotoxic to human cancer cells like HeLa and MDA-MB231.
- Induces apoptosis in cancer cells.
- Suppresses tumor growth and inhibits cell proliferation in vivo.
Medchemexpress LLC Genkwanin | 437-64-9 | 284.26 | 25 MG
Genkwanin is a major non-glycosylated flavonoid known for its anti-inflammatory activities. It is widely used in research and analytical applications as an analytical standard.
- Major non-glycosylated flavonoid
- Demonstrates anti-inflammatory activities
- Intended for research and analytical applications
- Analytical standard
Cayman Chemical ANTIBODY APHS 50mg
APHS is an O-acetyl, S-alkyl thio ether of 2-thio phenol. It is a potent inhibitor of both COX-1 and -2, with IC50 values of 17 and 0.8 µM for human recombinant COX-1 and -2, respectively.{6580} APHS exhibits 20-fold selectivity toward the inhibition of COX-2, yet it is still more potent than aspirin in the inhibition of COX-1. APHS acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition.{6580}
Medchemexpress LLC BMS-37 | 1675202-20-6 | C27H32N2O4 | 50 MG
BMS-37 is a potent PD-1/PD-L1 immune checkpoint inhibitor, demonstrating an IC50 towards the PD-L1/PD-L1 complex within the range of 18 to 200 nM. This compound is valuable for research into PD-L1-induced T-cell exhaustion or as a PD-L1 ligand for the synthesis of PROTAC molecules.
- Inhibits PD-1/PD-L1 immune checkpoint
- IC50 towards PD-L1/PD-1 complex between 18 to 200 nM
- Useful for studying PD-L1-induced T-cell exhaustion
- Can serve as a PD-L1 ligand for PROTAC molecule synthesis
ABclonal Technology CTP synthase / CTPS Rabbit mAb
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate) This reaction is an important step in the biosynthesis of phospholipids and nucleic acids Activity of this proten is important in the immune system and loss of function of this gene has been associated with immunodeficiency Alternative splicing results in multiple transcript variants
Cayman Chemical ANTIBODY VX-765 5mg
A prodrug form of VRT-043198; inhibits LPS-induced increases in serum IL-1β levels in mice at 50, 100, and 200 mg/kg; reduces oxazolone-induced EAr edema and levels of IL-1β, IL-18, and IFN-γ in EAr tissue in an oxazolone-sensitized mouse model of delayed-type hypersensitivity; reduces forepaw inflammation in a mouse model of collagen-induced arthritis in a dose-dependent manner; decreases seizure duration and the number of seizures in a mouse model of acute seizures induced by hippocampal kainic acid injection at ≥50 mg/kg, as well as delays the onset of seizures at 100 and 200 mg/kg; reduces the aggregated duration of epileptic activity in a mouse model of chronic epilepsy
Medchemexpress LLC (S)-SAR131675 | 1433953-83-3 | C18H22N4O4 | 50 MG
(S)-SAR131675 is the S-enantiomer of SAR131675, a potent and selective VEGFR3 inhibitor and a click chemistry reagent. This product is intended for research use only.
- Potent and selective VEGFR3 inhibitor
- Click chemistry reagent
- Intended for research use only
- S-enantiomer
Cayman Chemical 1 2DIstearoyld70snglycero 5mg
An internal standard for the quantification of 1,2-distearoyl-sn-glycero-3-PC by GC- or LC-MS
Cayman Chemical ANTIBODY Lu AF21934 5mg
A positive allosteric modulator of mGluR4 (EC50 = 500 nM for the human receptor in a FLIPR assay); selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, GPCRs, and enzymes at 10 μM; reduces marble burying behavior and stress-induced hyperthermia in mice at 12 mg/kg but also reduces locomotor activity; inhibits MK-801- and amphetamine-induced hyperactivity in mice; prevents MK-801-induced decreases in social interaction in rats; reduces harmaline-induced hyperactivity in rats at 0.5 and 2.5 mg/kg
Medchemexpress LLC Azido-PEG8-hydrazide | 2353410-11-2 | 96.1% | 481.54 g/mol | C19H39N5O9 | 5 MG
Azido-PEG8-hydrazide is an azide-terminated PEG8 linker with a hydrazide functional group, designed for use in click chemistry and as a versatile linker for assembling bifunctional molecules. It is provided as a solid for research applications and is compatible with common bioconjugation reactions.