Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,681 – 4,695 of 60,549 results

4,681

TARGETMOL CHEMICALS INC TC-I 2014 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. TC-I 2014 shows antiallodynic properties in pain models. TC-I 2014 is a potent and orally active Benzimidazole-containing transient receptor potential melastatin 8 antagonist (IC50 0.8 nM 3.0 nM and 4.4 nM for canine human and rat channels respectively). purity: 98%

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4,682

AdipoGen [10]-Gingerol (5 mg)

Chemical. CAS: 23513-15-7. Formula: C21H34O4. MW: 350.49. Isolated from plant source. 10-Gingerol is originally found in species of Zingiber. It exhibits antiemetic, anticancer, antioxidative, anti-inflammatory and antibiotic activities. 10-Gingerol increases radical scavenging of superoxide and hydroxyl radicals, inhibits oxidative burst activity and decreases expression of NO and PGE2 in vitro. It exhibits antioxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation. 10-Gingerol also inhibits 5-HT3 receptors. Additionally, 10-gingerol inhibits proliferation in different cancer cells. Shwon to suppresses IL-2-induced proliferation of T lymphocytes. This compound also displays antibacterial efficacy against gram negative bacteria such as Porphyromonas and Prevotella, antifungal and antiparasitic activity.

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4,683

Cayman Chemical Fidarestat, Purity: ≥95%, CAS: 136087-85-9, 10 mg

An aldose reductase inhibitor (IC50 = 0.026 μM); inhibits AKR1B10 (IC50 = 33 μM); decreases sorbitol and myo-inositol levels in the sciatic nerves of STZ-induced diabetic rats (2 mg/kg per day); decreases nerve fiber abnormalities and reverses slowing of MNCV in an STZ-induced diabetic rat model of peripheral neuropathy (2 mg/kg per day); decreases the pain threshold in STZ-induced diabetic mice overexpressing human aldose reductase (4 mg/kg per day); decreases metastasis in a KM20 human colorectal cancer mouse xenograft model (50 mg/kg per day)

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4,684

Sigma Aldrich Fine Chemicals Biosciences Forskolin from Coleus forskohlii, 98 (HPLC), powder, 66575-29-9, MFCD00082317

Forskolin from Coleus forskohlii, 98 (HPLC), powder

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4,685

Medchemexpress LLC EHT 1610 | 1425945-60-3 | 98.9% | 383.40 | 100 MG

EHT 1610 is a potent inhibitor of DYRK family kinases, demonstrating strong activity against DYRK1A and DYRK1B. This compound exhibits antileukemia effects, modulates the cell cycle, and is capable of inducing apoptosis in various cell types. It is suitable for research applications exploring kinase inhibition and its cellular impacts.

Potent inhibitor of DYRK1A (IC50: 0.36 nM) and DYRK1B (IC50: 0.59 nM).
Exhibits antileukemia activity.
Regulates cell cycle progression.
Induces cell apoptosis.
Inhibits DYRK1A-mediated FOXO1 and STAT3 signaling.
Reduces leukemic burden in in-vivo models.

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4,686

Cayman Chemical Ganglioside GM1 (bovine) (sodium salt), Purity: ≥98%, CAS: 37758-47-7, 5 mg

A mixture of ganglioside GM1 species isolated from bovine brain with primarily C18:0 acyl chain lengths; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson's disease; accumulates in neurons in ganglioside GM1 gangliosidosis

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4,687

Cayman Chemical Ambenonium (chloride), Purity: ≥95%, CAS: 115-79-7, 5 mg

An AChE inhibitor (IC50 = 0.7 nM); selective for AChE over BChE (IC50 = 6.82 µM); increases the secretion of APP in primary rat basal forebrain cells at 10 µM; induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats at 5 µg/animal; inhibits tubocurarine- or decamethonium-induced paralysis in anesthetized cats at 3 µg/animal

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4,688

Medchemexpress LLC R-zevaquenabant | 00-00-0 | 99.2% | 548.0 g/mol | C25H21ClF3N5O2S | 5 MG

(R)-Zevaquenabant is the R-enantiomer of Zevaquenabant (MRI-1867), a peripherally restricted, orally bioavailable dual cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS) antagonist. Supplied as a white to off-white solid in small research quantities, it is intended for in vitro and in vivo pharmacology studies exploring CB1/iNOS pathways. Manufacturer-reported purity and enantiomeric excess accompany the product.

High enantiomeric purity (ee 99.58%) and chemical purity (~99.15%).
White to off-white solid, easy to weigh and prepare.
Available in small research sizes for pilot experiments.
Suitable for CB1 receptor and iNOS pharmacology studies.
Characterized by formula C25H21ClF3N5O2S and molecular weight 548.0 g/mol.

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4,689

Cayman Chemical Iloperidone metabolite P95, Purity: ≥98%, CAS: 475110-48-6, 5 mg

A metabolite of iloperidone; binds to 5-HT2A receptors and α1-, α2B- and α2C-adrenergic receptors (mean Kis = 7.08, 21.38, 83.18, and 47.86 nM, respectively); does not cross the blood-brain barrier

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4,690

Cayman Chemical PFK15, Purity: ≥95%, CAS: 4382-63-2, 5 mg

A selective inhibitor of PFKFB3 (IC50 = 207 nM); rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice

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4,691

Cayman Chemical Lalistat 1, Purity: ≥98%, CAS: 501104-16-1, 1 mg

An inhibitor of lysosomal acid lipase (IC50 = 68 nM); selective for LAL over human pancreatic and bovine milk lipoprotein lipases up to a concentration of 10 µM; reduces cholesterol accumulation in lysosome-like storage organelles in NPC1-deficient GM03123 cells (0.01-10 µM)

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4,692

Cayman Chemical AtractylosIdepotasIum salt 5mg

A natural heteroglucoside that blocks mitochondrial ADP/ATP translocases, inhibiting oxidative phosphorylation

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4,693

Cayman Chemical GSK-J1 (sodium salt), Purity: ≥95%, CAS: 1797832-71-3, 5 mg

A potent, cell impermeable inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s = 18 and 56 µM, respectively as measured by mass spectrometry; IC50 = 60 nM in JMJD3 antibody-based assays)

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4,694

Medchemexpress LLC N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine | 1093100-40-3 | MFCD22571725 | 98.0% | C26H19ClN8 | 10MG

Raf inhibitor 1 is a potent small-molecule Raf kinase inhibitor that binds and stabilizes B-Raf in a DFG-out inactive conformation and suppresses proliferation in sensitive cancer cell lines such as A375 and HCT-116.

High potency against B-RafWT, B-RafV600E, and C-Raf (Ki: 1 nM, 1 nM, 0.3 nM).
High purity (98.03%) suitable for biochemical and cellular assays.
Solid form with good solubility in DMSO (50 mg/mL) for in vitro use.
Formulations available for in vivo dosing (clear or suspended solutions at ≥2.5 mg/mL).
Stable under recommended storage conditions for long-term use.

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4,695

Medchemexpress LLC Spiperone hydrochloride | 2022-29-9 | 99.0% | 5 MG

Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective antagonist for the dopamine D2 receptor (with Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, and ~3500 nM for D2, D3, D4, D1, and D5 receptors, respectively) and the 5-HT2A/5-HT1A receptors (with Kis of 1 nM/49 nM). It also acts as a selective α1B-adrenoceptor antagonist and activates the calcium-activated chloride channel (CaCC). This compound exhibits antipsychotic and anti-inflammatory activities and is intended for research use only.

Selective dopamine D2 receptor antagonist
Antagonizes 5-HT2A/5-HT1A receptors
Selective α1B-adrenoceptor antagonist
Activates calcium-activated chloride channel (CaCC)
Demonstrates antipsychotic activity
Exhibits anti-inflammatory activities

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Bioactive Small Molecules

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Medchemexpress LLC EHT 1610 | 1425945-60-3 | 98.9% | 383.40 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC R-zevaquenabant | 00-00-0 | 99.2% | 548.0 g/mol | C25H21ClF3N5O2S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine | 1093100-40-3 | MFCD22571725 | 98.0% | C26H19ClN8 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Spiperone hydrochloride | 2022-29-9 | 99.0% | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EHT 1610 | 1425945-60-3 | 98.9% | 383.40 | 100 MG

Medchemexpress LLC R-zevaquenabant | 00-00-0 | 99.2% | 548.0 g/mol | C25H21ClF3N5O2S | 5 MG

Medchemexpress LLC N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine | 1093100-40-3 | MFCD22571725 | 98.0% | C26H19ClN8 | 10MG

Medchemexpress LLC Spiperone hydrochloride | 2022-29-9 | 99.0% | 5 MG